Lead engineer – Bioprocess Integration (Purification)

Slough, England, United Kingdom

12/6/2024

Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Role Purpose

Design, plan, and complete studies in support of downstream integration and technology development projects with well-defined scope and timelines. Analyse study data to drive conclusions and contribute to world-class bioprocess solutions.

Delivery

• Develop innovative and robust intensification strategies for protein purification.
• Perform data trending and manufacturing cost analysis to benchmark process intensification strategies.
• Collaborate with relevant collaborators to define the requirements for coordinated protein purification in a manufacturing setting and build the development plan.
• Develop procedures to ensure equipment and unit operations are compatible with integration and automation.
• Define the strategy for the monitoring and control of coordinated protein purification.
• Establish coordinated purification process at lab-scale in collaboration with automation and digitalization specialists.
• Independently design studies, collate, evaluate/analyse and interpret complex data sets to achieve project targets.
• Develop and implement comprehensive study plans with designated timelines.
• Author technical reports and publications with scientifically supported conclusions and recommendations.
  
  

Work Practices

• Maintain accurate and timely records to appropriate quality standards for self and team, preparing high-quality technical analyses and reports for internal or external use.
• Support team resource planning, project management activities, and prioritisation decisions.
• Adhere to good laboratory practices and support housekeeping and maintenance activity.
• Maintain documentation describing configurations and setup of coordinated process, process flow sheets, and cost models.
  
  

Key skills

• Knowledge of downstream unit operations (separation basics, mass balance).
• Knowledge of bioprocess equipment, sophisticated automation, and controls at lab scale.
• Demonstrated expertise in configuring lab scale equipment for coordinated downstream processing.
• Hands-on experience in setup, execution, and troubleshooting of downstream process intensification experiments using AKTA or appropriate filtration (Depth, UF/DF) setup.
• Compile data, perform data analysis, and conclude observations (e.g., data trending, chromatogram traces, MVDA, etc.).
• Proficiency in using tools vital for data extraction, compilation, analysis, and presentation.
  
  

Other Desired Skills

• Maintain accurate and timely records to appropriate quality standards for self and team, preparing high-quality technical analyses and reports for internal or external use.
• Support team resource planning, project management activities, and prioritisation decisions.
• Adhere to good laboratory practices and support housekeeping and maintenance activity.
• Maintain documentation describing configurations and setup of coordinated process, process flow sheets, and cost models.
  
  

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.