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Copyright © 2026
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About us
The Cancer Research UK & UCL Cancer Trials Centre (CTC) is one of the largest and most established cancer clinical trials units in the UK, delivering high-quality Phase I-III studies that have changed national and international clinical practice.
Based within University College London (UCL) and funded by organisations including Cancer Research UK, the Centre brings together clinicians, scientists and professional services specialists to design and deliver complex oncology trials across the UK and internationally.
With over 120 staff working across around 100 active studies, the CTC operates at real scale - covering early and late-phase trials, adult and paediatric populations, and innovative treatments including immunotherapies, radiotherapy, advanced targeted drugs, and cell and gene therapies.
The CTC sits within the UCL Cancer Institute, home to more than 400 scientists translating discovery science into safer, more effective cancer treatments. Together, our mission is to improve outcomes for patients through high-quality, ethical and well-governed clinical research.
About the role
We are seeking an experienced Clinical Trials Operations Manager (Regulatory) to join the CTC Senior Management Group and provide strategic operational leadership across our regulatory-critical functions.
This is a senior, influential role with real autonomy. You will have oversight of:
Quality Assurance
Pharmacovigilance
Monitoring
Key elements of data management infrastructure
Working closely with the CTC Director, Clinical Leads and senior colleagues, you will shape how trials are set up, governed and delivered - ensuring compliance with GCP, MHRA and HRA requirements, while also improving efficiency, systems and timelines across a complex and varied portfolio.
You will:
Lead and develop Grade 7 and 8 operational specialists
Streamline and modernise SOPs, systems and infrastructure
Play a key role in MHRA inspection readiness
Act as a senior point of contact with regulators and partners
Represent the CTC at national and international forums
Contribute to centre-wide strategy and cross-CTU collaboration at UCL
This role is not about day-to-day trial delivery. It is about setting direction, solving complex problems, and enabling others to deliver safely, efficiently and at scale.
The post is funded for three years in the first instance, on a renewable Cancer Research UK programme grant.
About you
We're looking for someone who already operates comfortably at senior CTU or sponsor level and wants to apply their expertise in a large, high-impact academic trials environment.
You will bring:
High-level knowledge of UK (and EU) clinical trials regulation, including pharmacovigilance
Strong understanding of QA, monitoring and clinical data management
Experience delivering IMP trials (licensed and unlicensed)
Confidence providing regulatory leadership and judgement, not just compliance
Proven line management and leadership experience
The ability to improve systems and infrastructure, not simply maintain them
A pragmatic, solutions-focused approach to complex operational challenges
You enjoy working independently, influencing senior stakeholders, and balancing regulatory rigour with real-world delivery in a collaborative, multidisciplinary setting.
What we offer
The opportunity to play a senior leadership role in one of the UK's most respected cancer trials centres
Work that has direct, measurable impact on patient care and clinical practice
A supportive, expert and highly collaborative culture
Hybrid working with flexibility around start and finish times
(staff are expected to work on site around 60% FTE, typically 3 days per week for full-time roles)
Competitive Grade 9 salary (£68,284-£76,244 per annum, including London Allowance)
Access to UCL's extensive professional development, wellbeing and benefits package
UCL is consistently ranked among the world's leading universities and is committed to inclusive, sustainable and flexible ways of working.
Visit https://www.ucl.ac.uk/work-at-ucl/rewards-and-benefits to find out more.
Our commitment to Equality, Diversity and Inclusion
As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.
We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce.
These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
Our department holds an Athena SWAN Gold award, in recognition of our long-term commitment and 'beacon' status in advancing gender equality.