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Job Overview
To lead new evaluations regarding pharmacokinetic and pharmacodynamic (PKPD) for pulmonary optimization within the PKPD laboratory (Research Microbiology Department).
To Work Closely With The Consultant Respiratory Physician And Head Research Scientist In The PKPD Lab To Ensure The Management Of Simulations Is Of a High Quality And To Take Responsibility For
High quality data
MIC studies
- Time Kill Curve evaluations
- Immunoassay and liquid chromatographic assays, including the operation, maintenance and management of HPLC systems within the ARL laboratory.
- Development of PKPD models
- Method development of respiratory agents
- Providing specialist microbiology susceptibility and molecular tests
- The role will also include assistance in North Bristol Trusts NIHR CRN Portfolio and other microbiology research projects. The post holder will be required to work alone and participate in regular out of hours working
Main duties of the job
Practical responsibilities
- Implement the setup and running and, quality assure the data generated from pharmacodynamic models as designed to investigate the interactions of antibiotics on bacteria in a research setting
- Ensure accurate data collection and analysis as appropriate using Excel and Word and specialist software such as Graph Pad Prism.
- Measurement, analysis and quality assure antimicrobial agents used in PK/PD studies by immunoassay, liquid chromatography or bio-assay
- Perform tests to assess the susceptibility of bacteria to antibiotics by both routine and specialist techniques, including disc methods, agar and broth dilution methods, E test, and antibiotic – antibiotic interaction studies
- To support the line manager in the delivery of Pharma, NBT and NIHR-CRN research projects
Working for our organisation
North Bristol NHS Trust employs over 12,000 staff providing healthcare to the residents of Bristol, South Gloucestershire and North Somerset from our award-winning hospital building at Southmead. We are the regional Major Trauma Centre, and an internationally recognised centre of excellence in a range of services and major specialities. Our vision is that by enabling our teams to be the best that they can be, we will provide exceptional healthcare, personally delivered.
North Bristol NHS Trust values all people as individuals. We aim to be an anti-discriminatory organisation and are committed to building a team that represents a variety of backgrounds, perspectives, and skills. We welcome applicants from all underrepresented groups.
Detailed Job Description And Main Responsibilities
Knowledge
- A relevant science degree, or post graduate degree with equivalent specialist experience
- 1 year practical experience in PKPD in vitro modelling, MIC science is essential
- 1 year practical and appropriate theoretical knowledge of analytical techniques including susceptibility testing; determination of resistance mechanisms and bacterial identification using molecular techniques
- Experience working in a research team is essential
- Able to maintain and demonstrate a high level of practical competence and willingness to undertake further training as required
- Knowledge of laboratory polices, codes of practice and professional guidelines
- Knowledge of health and safety issues pertinent to laboratory work
Skills
Under the direction of the Lead Research Clinical Scientist -
- Organize the day to day running of the respiratory PKPD simulations
- Undertake a range of diagnostic tests relevant to the area of work
- Present data both written and oral including laboratory reports
- Plan, prioritize, implement and evaluate own workload and workload for support team
- Teach and supervise non-professionally qualified staff ( if required)
- Use NBT Clerical and IT skills
- Work independently and be able to develop good relationships with colleagues, and external collaborators.
- Maintain and demonstrate a high level of practical competence and willingness to undertake further training as required
For Further Details / Informal Visits Contact
Person specification
written
Essential criteria
- PKPD practical experience
- Performed PhD studies
- Microbiology practical experience
- Experience of trouble shooting
Desirable criteria
- Training experience
- Working as part as a team and independently
Verbal
Essential criteria
Desirable criteria
If you apply for this vacancy and have not received a communication from North Bristol NHS Trust within three weeks of the closing date, please assume that on this occasion your application has been unsuccessful.
Please note that North Bristol NHS Trust does not reimburse travel expenses relating to interview attendance.
If you feel you meet the requirements of the Disability Act / Two Ticks scheme and require further support/advice, please contact us on tel 0117 414 1151.
North Bristol NHS Trust are committed to safeguarding and promoting the welfare of children and young people and expects all staff and volunteers to share this commitment.
The successful applicant(s) will normally commence at the minimum of the scale unless they have previous NHS service at the same band. Progression through the scale is by annual increments.
At North Bristol Trust (NBT), we know diverse and inclusive environments lead to happier and healthier teams and improved patient care and outcomes. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are currently underrepresented in NBT’s workforce at Band 8a and above. These include people from Black, Asian and minority ethnic backgrounds, disabled people and LGBTQIA+ people.
Please note that stringent pre-employment checks are undertaken on all successful applicants prior to commencement in post.
