Postdoctoral Fellow - Gene Regulation and Functional Genomics
Company
Location
Hinxton, England, United Kingdom
Posted At
9/15/2025
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Description
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.
We have an exciting opportunity for two Postdoctoral Fellow's (PDF) to join the Taipale group for a 3-year fixed-term contract with the potential to extend at Wellcome Sanger Institute.
About The Role
The laboratory consists of experimental biologists and computer scientists who focus on the study of transcriptional control of cell growth, using functional genomics, systems biology, and mouse genetic models. This position will particularly suit candidates who are willing to develop new, long-term, scalable projects that fits within the remit of the lab.
You Will Be Responsible For
You should have, or will soon have, a PhD in computational biology, molecular biology, genetics, or biochemistry.
You will have flexibility within the role to pursue an independent research project in the general remit of gene expression and the lab. Candidates with interest or experience in machine learning, artificial intelligence and programming are encouraged to apply.
You will also have excellent communication skills and the ability to communicate effectively with stakeholders.
Essential Technical Skills
The Taipale group is newly established at the Wellcome Sanger Institute within the Generative and Synthetic Genomics programme. Our overarching aim is to solve the sequence-to-function problem: how gene function and regulation is encoded in DNA sequences. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors using SELEX and fiber-seq and assessing the activity of random DNA within cells. We then use this experimental data to create AI models to identify regulatory elements that control cell growth during normal development and in cancer.
The lab also benefits from access to cutting-edge facilities at the Wellcome Sanger Institute and close collaboration with other groups at the Sanger and further afield.
This is a well-resourced setting where you’ll have the chance to broaden your skills, make a real contribution, and prepare for the next stage in your career.
For more information about being a Postdoctoral Fellow with us, please visit: https://youtu.be/1-vxm2nBmFA
Other Information
Please apply with your CV and a Cover Letter outlining how you meet the criteria set out above, why you are interested in joining the Taipale group, and some ideas on future projects.
Salary: £38,000 - £49,156 depending on experience Role profile
Contract Type: 3 years fixed term (Core funding)
Recruitment Process: Zoom interviews 29th Oct / 31st Oct, Face to face Interviews w/c 10th November 2025 (subject to change)
Closing Date: 17th October 2025
Hybrid Working At Wellcome Sanger
We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.
Equality, Diversity And Inclusion
We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.
We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
Our Benefits
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.
Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.
We have an exciting opportunity for two Postdoctoral Fellow's (PDF) to join the Taipale group for a 3-year fixed-term contract with the potential to extend at Wellcome Sanger Institute.
About The Role
The laboratory consists of experimental biologists and computer scientists who focus on the study of transcriptional control of cell growth, using functional genomics, systems biology, and mouse genetic models. This position will particularly suit candidates who are willing to develop new, long-term, scalable projects that fits within the remit of the lab.
You Will Be Responsible For
- Development of an independent research direction within the interests of the lab that should use the local expertise and technology
- Writing up manuscripts, communicating results through talking, presenting posters at scientific meetings
- Collaborate with internal teams and external collaborators to ensure project progress and provide regular updates
- Taking an active part in your development, including attending training and being an active member of our Postdoctoral Fellow community
You should have, or will soon have, a PhD in computational biology, molecular biology, genetics, or biochemistry.
You will have flexibility within the role to pursue an independent research project in the general remit of gene expression and the lab. Candidates with interest or experience in machine learning, artificial intelligence and programming are encouraged to apply.
You will also have excellent communication skills and the ability to communicate effectively with stakeholders.
Essential Technical Skills
- PhD in relevant subject area, or on track to be awarded your PhD within 6 months of starting the role
- Proven ability to deliver research projects
- A track record of demonstrating research excellence and expertise in your area of research
- Familiarity with chromatin and gene expression research
- Ability to analyse and interpret data with strong quantitative/computational skills
- Programming and bioinformatics skills
- Experience with mammalian tissue culture
- Familiarity with current gene editing techniques e.g. CRISPR, BxbI integrases
- Previous work experience in a molecular biology laboratory
- Experience with core molecular biology techniques e.g RT-qPCR and RNA/DNA extraction
- Proven ability to develop and maintain effective working relationships with wide range of persons of differing level, abilities and knowledge
- Foster an inclusive culture where all can thrive and diversity is celebrated (E)Team player with the ability to work with others in a collegiate and collaborative environment
- Ability to effectively communicate ideas and results and present orally to groups
- Commitment to personal development and updating of knowledge and skills
- Ability to priortise, multi-task and work independently
- Detailed orientated, strong organizational and problem-solving skills
The Taipale group is newly established at the Wellcome Sanger Institute within the Generative and Synthetic Genomics programme. Our overarching aim is to solve the sequence-to-function problem: how gene function and regulation is encoded in DNA sequences. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors using SELEX and fiber-seq and assessing the activity of random DNA within cells. We then use this experimental data to create AI models to identify regulatory elements that control cell growth during normal development and in cancer.
The lab also benefits from access to cutting-edge facilities at the Wellcome Sanger Institute and close collaboration with other groups at the Sanger and further afield.
This is a well-resourced setting where you’ll have the chance to broaden your skills, make a real contribution, and prepare for the next stage in your career.
For more information about being a Postdoctoral Fellow with us, please visit: https://youtu.be/1-vxm2nBmFA
Other Information
Please apply with your CV and a Cover Letter outlining how you meet the criteria set out above, why you are interested in joining the Taipale group, and some ideas on future projects.
Salary: £38,000 - £49,156 depending on experience Role profile
Contract Type: 3 years fixed term (Core funding)
Recruitment Process: Zoom interviews 29th Oct / 31st Oct, Face to face Interviews w/c 10th November 2025 (subject to change)
Closing Date: 17th October 2025
Hybrid Working At Wellcome Sanger
We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.
Equality, Diversity And Inclusion
We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.
We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
Our Benefits
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.
Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.
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