Postdoctoral Fellow – Haematopoietic Stem Cell Lab

Postdoctoral Fellow – Bonnet Lab

Job title: Postdoctoral Fellow – Haematopoietic Stem Cell Lab

Reports to: Dominique Bonnet, Principal Group Leader

Contract: This is a full-time fixed term position for 4-year on Crick Terms & Conditions of employment

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

The Haematopoietic Stem Cell Lab works on the regulation of human normal haematopoietic stem cell biology and leukemia and the role of the extracellular factors providing by the niche.

We are looking for a productive and motivated Postdoctoral Fellow with a desire to work in a congenial, dynamic and collaborative research team. You will be part of the team of researchers working in the Haematopoietic Stem Cell laboratory under the direction of Prof Dominique Bonnet.

The group is interested in studying normal human Haematopoietic Stem Cells (HSCs) and Leukaemic Stem Cells (LSCs). At present we are investigating the relationship between normal HSCs, LSCs and their microenvironment. We are also interested in understanding how pre-leukaemic mutations provide a clonal advantage overtime, what are the external factors involved in this selection and how to potential revert it.

As a Postdoctoral fellow in the HSC team, you will be responsible for leading an independent research project within the lab, playing a key role in driving the overall direction of the project under the supervision of Prof D Bonnet.

See here for more details of research projects currently being undertaken in HSCL lab.

Please see the full job description here.

What you will be doing

As a Postdoctoral Fellow at the Crick, you will:

• Design and perform experiments, and analysis data, with the strongest possible research integrity.
• Keep up with relevant scientific literature to identify key challenges in the field.
• Reporting, presenting and discussing results with people in the group during lab meeting
• Presenting and reporting results with D Bonnet in a regular basis.
• Preparing /drafting your own research paper or writing reviews
• Collaborate with others in the lab and/or institute and with the scientific facilities in the institute where appropriate.
• Collaborate with external researchers if /when the project requires it.

About you

You will have:

• PhD on stem cell and/or cancer biology,
• Experience FACS analysis/sorting
• Experience in molecular biology
• Experience in modulating gene expression via lentivirus and/or Crisp-Cas9 editing,
• Experience on haematopoietic field
• Proven track record of research (e.g: publication record)

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
• We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: [email protected]

Find out more about life at the Crick.

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK
• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
• Health & Well-being:
• 24/7 GP consultation services.
• Occupational health services and mental health support programs.
• Eye care vouchers and discounted healthcare plans.
• Work-Life Balance:
• Back-up care for dependents.
• Childcare support allowance.
• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.
• Perks:
• Discounted gym memberships, bike-to-work scheme, and shopping discounts.
• Subsidised on-site restaurant and social spaces for team interaction.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed.

We reserve the right to withdraw this advert at any given time due to the number of applications received.