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Postdoctoral Project Research Scientist - Ultanir Lab (Francis Crick Institute) & Isalan Lab (Imperial College London)
About us
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role
This role is a joint collaboration between Sila Ultanir at the Francis Crick Institute and Mark Isalan at Imperial.
The Ultanir lab studies the roles of protein kinases in neuronal development and function. The Isalan lab has long worked on a zinc finger engineering platform for gene therapy (PMID 11433278, 23054839, 27600816).
We are recruiting a motivated postdoctoral scientist to join the labs of Kinases and Brain Development https://www.crick.ac.uk/research/labs/sila-ultanir at the Francis Crick Institute, London, UK and Mark Isalan at Imperial College London https://profiles.imperial.ac.uk/m.isalan. The postdoctoral scientist will run a translational project to develop zinc finger protein transactivators for treatment of a neurodevelopmental disorder.
In this project, we aim to develop ZFPs which can upregulate CDKL2 mRNA expression and test if these can rescue molecular, cellular and behavioural defects in CDKL5 deficiency models. Postdoctoral researcher will generate and test zinc finger protein transactivators. They will then use CDKL5 knockout mouse models to determine if they can restore CDKL5-mediated functions at molecular and behavioural level. iPSC derived neurons of CDD models and proteomics will also be used to test rescue of phosphorylation substrates. Postdoctoral researcher will lead their own projects, contribute to other projects on a collaborative basis and help train PhD students.
To see the full job description, click here.
About you
The post holder should embody and demonstrate our core Crick values:
Bold; Open; Collegial
Essential
Desirable but not essential
To see more about the lab, click here.
About Working at the Crick
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: [email protected]
To find out more about life at the Crick click here.
What will you receive?
At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: