Preclinical Pharmacology Consultant (Peptide Therapeutics)

Who we are:

Life Reimagined

Constructive Bio is a VC-backed biotechnology startup based in Whittlesford, Cambridge. Our breakthrough technology harnesses the power of genome rewriting and genetic code reprogramming to make valuable products that positively impact the world. We will use our platform to turn cells into bio-renewable factories to produce novel molecules that were previously inaccessible to natural biology, with diverse applications in industries spanning healthcare, biological research, materials and electronics.

Constructive Bio is a spinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. Learn more about the Chin lab achievements here:

https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/

We want to build a team with trust and respect for each other and create a culture of accountability, collaboration, openness, curiosity, and scientific excellence.

We are built on three principles:

• We imagine: We think big and plan our own path for success.
• We pioneer: We take action and grow together as one to break moulds.
• We deliver: We take ownership and work together to deliver excellence.

What we’re looking for:

Constructive Bio is seeking an experienced DMPK or PK/PD (Preclinical Pharmacology) Consultant to support ASAP the design and delivery of our peptide development programs. Our pipeline includes engineered peptides incorporating non-canonical amino acids, and we need expertise to translate molecular design into clear DMPK strategies and data packages. We need someone experienced available now.

Scope of work:

• Plan and review in vivo studies (PK, bioavailability, half-life, clearance routes, immunogenicity considerations).
• Plan and review in vitro assays (plasma stability, protease resistance, plasma protein binding, permeability).
• Advise on overall DMPK strategy for peptides, including study design, interpretation, and regulatory expectations.
• Analyse data, highlight risks, and recommend next steps to guide project teams.
• Benchmark against industry best practices and prepare input suitable for preclinical packages.
• Support vendor/CRO selection and study oversight.

Requirements:

• Track record in DMPK for peptides or biologics, ideally in pharma/biotech. Evidence for the track record needs to be provided.
• Experience with PK/PD modelling, half-life extension technologies, and translation from animal to human.
• Ability to work flexibly as a consultant, providing both strategic guidance and hands-on analysis.
• Strong communication skills to work with internal scientists and external partners.

Desirable:

• Experience of in vitro and in vivo safety and toxicology studies
• Knowledge and preparation of IND documents would be an advantage

We are open to short- or medium-term consulting arrangements.