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The role
Respiratory viruses contribute to the development and exacerbation of chronic lung diseases such as chronic obstructive pulmonary disease (COPD). Respiratory syncytial virus (RSV) is a significant childhood pathogen and is increasingly recognised as a pathogen of importance in older adults. The majority of older adults admitted to hospital with RSV infection have an underlying health condition, of which COPD or asthma is a significant proportion (27.3%) and was associated with increased requirement for ventilatory support. RSV has also been identified as the infectious agent responsible for 8.7% of out-patient managed exacerbations of COPD (8.7%).
Using both traditional cell culture approaches and advanced 3D airway cell models, this project will investigate if a newly developed COPD treatment could prevent RSV-induced inflammation and cellular changes that contribute to lung remodelling and exacerbations of lung disease.
The post holder will contribute to the day-to-day running of the laboratory and supervision of undergraduate and postgraduate students. It is also expected the successful candidate will contribute to the writing and submission of high-quality research publications and deliver scientific presentations at national and international conferences.
About You
Candidates should have a higher research degree (PhD) in a relevant subject such as cell biology, immunology or virology. Expertise with mammalian cell culture is essential. Experience with differentiated or primary cell modelsis highly desirable. Knowledge of cell biology and immunological assays such as ELISA, western blot, confocal microscopy, RT-qPCR is required
How to apply
To apply please submit your CV and a cover letter outlining your suitability for the role via our website. Informal enquires can be directed to Dr Lindsay Broadbent (
[email protected])
