Research Scientist Protein Mass Spec
Company
Location
Oxford, England, United Kingdom
Posted At
8/8/2025
Disclaimer: Hunt UK Visa Sponsors aggregates job listings from publicly available sources, such as search engines, to assist with your job hunting. We do not claim affiliation with Vertex Pharmaceuticals. For the most up-to-date job details, please visit the official website by clicking "Apply Now."
Description
Job Description
Vertex is currently seeking a highly motivated Research Scientist with a strong background in Mass Spectrometry (MS) and proteomics to join our Protein MS team, in our Structural Biology and Biophysics Department in Oxford, UK. This team supports projects from early stage through to preclinical and provides a global capability in state-of-the-art protein mass spectrometry. The position requires experience in the design, preparation, execution and analysis of unbiased proteomics and targeted quantitative protein/peptide assays to interrogate disease biology and enable small molecule drug discovery. Excellent communication skills are required as is a strong ability to work in a team. Experience with other MS techniques such as small molecule, Intact Mass, Native, HDX, or PTM characterisation would be desirable.
As a key player within a vibrant and expanding multi-disciplinary drug discovery team you will be exposed to every aspect of drug discovery and development in one of the world’s leading biotechnology companies.
Key responsibilities:
Key Requirements
On-Site Designated
Flex Eligibility Status
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]
Vertex is currently seeking a highly motivated Research Scientist with a strong background in Mass Spectrometry (MS) and proteomics to join our Protein MS team, in our Structural Biology and Biophysics Department in Oxford, UK. This team supports projects from early stage through to preclinical and provides a global capability in state-of-the-art protein mass spectrometry. The position requires experience in the design, preparation, execution and analysis of unbiased proteomics and targeted quantitative protein/peptide assays to interrogate disease biology and enable small molecule drug discovery. Excellent communication skills are required as is a strong ability to work in a team. Experience with other MS techniques such as small molecule, Intact Mass, Native, HDX, or PTM characterisation would be desirable.
As a key player within a vibrant and expanding multi-disciplinary drug discovery team you will be exposed to every aspect of drug discovery and development in one of the world’s leading biotechnology companies.
Key responsibilities:
- Design and execute novel quantitative mass spectrometry assays for peptides and proteomics, including analysis of protein PTMs (e.g. glycosylation, ubiquitination).
- Design, develop and optimize methods in chemoproteomics to identify small molecule target engagement.
- Develop and optimize workflows from sample preparation to data acquisition and data analysis, including statistical analysis.
- Work across multiple MS techniques (protein characterisation, small molecule, peptide mapping)
- Support running of MS instruments and take responsibility for routine upkeep.
- Deliver results in a fast-paced and dynamic research environment and be willing to learn new techniques and technologies as required by the role.
- Organise, record, and report results according to data integrity guidelines.
- Interpret and explain results to cross-functional teams.
Key Requirements
- Relevant Ph.D. or equivalent experience with proven track record of mass spec delivery
- Demonstrated track record of method development and application of common proteomics and MS acquisition and labelling techniques such as PRM, DDA, DIA, LFQ, SILAC, TMT, dimethyl etc
- Experience with data analysis software packages such as MaxQuant, Skyline, DIA-NN, Spectronaut.
- Practical experience working with a variety of MS systems, experience with Thermo Orbitrap instruments is essential.
- Hands-on experience troubleshooting complex instrumentation.
- Experience with sample prep, peptide enrichment and mass spectrometry method development and optimisation.
- Ability to comfortably manipulate, analyse and interpret complex data.
- Self-driven ability to organize resources and data, manage time and priorities.
- Desire to work in a fast, collaborative, and team-oriented environment.
- The ability to communicate clear and concise updates across a variety of audience levels, keep track of experimental records and results.
- Demonstrated ability to work as part of a multidisciplinary team.
- Familiarity with other protein MS techniques such as Intact Mass, Native, HDX, MS Imaging.
- Experience with glycoproteomics or glycomics methods.
- Experience running and analysing quantitative small molecule mass spec assays.
- Demonstrable leadership for promoting innovation in those techniques and to troubleshoot problems as they arise
- Experience of working within the drug discovery industry
On-Site Designated
Flex Eligibility Status
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]
Hunt UK Visa Sponsors
Copyright © 2025