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Enara Bios purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines.
Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK.
Role Overview
A temporary full-time role has opened in the Cell and Immunobiology function at Enara Bio to assist for a period of six months. We are looking for a Scientist or Senior Scientist who has a deep passion for immunology and the role of T-cells in the exciting field of immuno-oncology. We want you to help to build an understanding of human T-cell biology against Enara Bio's novel tumour-specific antigens and translate this understanding into transformative products that enhance the anti-tumour T cell response in the tumour microenvironment. This is an opportunity for an innovative scientist to discover and develop an early stage product through to clinical application.
The candidate will be expected to play an active role in performing Lab-based Immunobiology assays in addition to helping in preparation for upcoming projects in lab and non-lab roles.
Due to the short-term nature of this fixed-term contract, we are unfortunately unable to offer visa sponsorship. Applicants must have the existing right to work in the UK for the duration of the contract.
Role Requirements
You will be responsible for:
- Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams
- Senior Scientist- Providing scientific coaching and mentorship for less experienced scientists in the team, as well as other scientists in our matrixed environment
- Senior Scientist- Providing expert technical direction, challenge and problem solving in projects
- Working closely with other research functional teams (e.g. Bioinformatics and Immunopeptidomics) to validate the role of novel T cell antigens and cognate T cell receptors in cancer
- Designing, conducting and evaluating experiments to establish the efficacy of T cell receptors against novel cancer antigens
- T cell profiling for very low frequency cells (use of ELISpot, multimers), FACS sorting/analysis, CTL cloning and recombinant T cell receptor expression/characterization. Killing assays using impedence-based and imaging methodology
Qualifications And Experience Required
Scientist
- Proven experience of working with CAR-T/TCR-T or T cell engager methodologies ideally in a biotech setting or alternatively in an academic setting
- Proven experience of working on cell or protein-based therapies
- Proven experience of relevant Immunological laboratory techniques
Senior Scientist
- Proven experience of working with CAR-T/TCR-T or T cell engager methodologies ideally in a biotech setting or alternatively in an academic setting
- Proven experience of working on cell or protein-based therapies
- A PhD in a relevant scientific discipline, strong expertise in immunology preferred, or demonstrable industry experience
- Proven experience of relevant Immunological laboratory techniques
- Previous proven experience of mentoring other scientists
Further Information
The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:
Empowerment: We promote autonomy across Enara rejecting conventional hierarchy. We engage each other through transparency, collaboration and trust. We each take action with a deep sense of personal and shared accountability.
Courage: We push boundaries in all that we do to deliver on our purpose. We make bold decisions, embrace risk and tackle challenges to advance our novel science. Courage is essential for everything we do.
Humility: We are proud of and excited by our novel science, but we acknowledge that we cannot know everything. Our curiosity drives us to continually learn from each other & the outside world irrespective of our role or title. We give and receive feedback with no room for ego.
Growth: We invest in our people, culture and community to foster belonging as a foundation for success. We embrace individual development to create deeper personal fulfilment and drive stronger collective impact.
We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.
Enara Bio Limited is an equal opportunities employer.
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