Senior Postdoctoral Researcher (Computational Genomics)

We are looking for a motivated computational biologist to join Marketa Tomkova’s group at the Ludwig Institute for Cancer Research, University of Oxford. The project investigates how Myeloproliferative Neoplasms (MPN) progress to secondary Acute Myeloid Leukaemia (sAML), an aggressive blood cancer with few treatment options.

You will lead the development of computational approaches to integrate multi-omics data (DNA methylation, histone modifications, single-cell transcriptomics, chromatin accessibility, and others) from patient samples, making use of TAPS sequencing – an in-house technology that detects DNA methylation and genetic variation simultaneously. The role also offers opportunities to contribute to study design and experimental planning, and to collaborate closely with clinicians, experimentalists, and computational scientists in a multidisciplinary consortium.

What we’re looking for

• High motivation and curiosity, with readiness to dive into sAML biology and drive innovative analyses
• PhD/DPhil in genomics, computational biology or a related field
• Strong programming skills (R or Python)
• Experience in large-scale genomics analysis, ideally single-cell and/or epigenetics
• Strong publication record and collaborative mindset

What we offer

• A vibrant, supportive work environment in a core-funded Oxford institute
• Mentoring and career development support towards independence
• Flexible working (up to 3 days from home)
• Excellent benefits including pension, childcare support, family leave, and travel schemes