Senior Quality Control Scientist

Job id: 092217

Salary: £34,189 - £40,792 per annum inclusive of London Weighting Allowance per annum.

Business unit: Faculty of Life Sciences & Medicine

Department: Comprehensive Cancer Centre.

Location: Denmark Hill

About us:

The King’s College London Gene Therapy Vector Facility (GTVF) provides comprehensive GMP-grade viral vector manufacturing services. This includes Lentiviral Vector (LV), Retroviral Vector (RV) and Adeno-Associated Viral Vector (AAV) production for early-phase clinical trials, alongside substantial programmes in process innovation, knowledge transfer and training to address critical skills shortages.

In partnership with the Network of Innovation Hubs, our vision is to ensure that the UK capitalises on its outstanding academic medical research to deliver novel gene therapies to patients, providing transformative treatments for currently intractable conditions, and generating a vibrant economic landscape.

The GTVF is run by a large, industry-leading team of >50 people who have extensive experience in delivering end-to-end viral vector manufacture for both academic and commercial clients, with a focus on early-stage clinical trials.

About the role:

The Senior QC Scientist will be responsible for the carrying out in-house quality control (QC) testing of cell and gene therapy products manufactured by the Cell and Gene Therapy (CGT) group as investigational medicinal products (IMPs) and as starting materials for further IMP manufacture. The role holder will ensure compliance of the QC testing with GLP, GMP and ICH guidelines as applicable. Assays will include but not be limited to, flow cytometry-based assays, cell proliferation assays, protein assays and western blots and molecular based methods e.g., QPCR.

The role holder will lead on the development, validation, and establishment of a broad range of start-of-the-art new in-house QC assays and work with external collaborators / clients on the tech transfer of QC assays into the CGT group. The maintenance of stability programs in conjunction with the Head of Quality and supervision of members of the QC team will also be undertaken by the role holder.

Working as part of a multidisciplinary team (quality assurance, production, process development) the Senior Quality Scientist will support the process development of manufacturing processes with regards to establishment of in-process and QC testing programmes.

This is a full-time post, and you will be offered an indefinite contract.

Contact details: Praveen Ramakrishnan. [email protected]

Closing date: 10 July 2024.

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