Translational PKPD (DMPK) Internship

Cambridge

AstraZeneca is a global, science-led biopharmaceutical business and its innovative medicines are used by millions of patients worldwide. AstraZeneca Summer Internships introduce you to the world of ground-breaking drug development, embedding you in highly dedicated teams, committed to delivering life-changing medicines to patients. Our 10–12-week program is designed for undergraduate, master's, and doctoral students. We offer exciting opportunities across Research & Development, Operations, and Enabling Units (Corporate functions).

Our internships immerse students in the pharmaceutical industry, allowing the opportunity to contribute to our diverse pipeline of medicines whether in the lab or outside of it. You will feel trusted and empowered to take on new challenges, but with all the help and guidance you need to succeed. This internship will help you develop essential skills, expand your knowledge, and build a network that will set you up for future success. You will be surrounded by curious, passionate, and open-minded professionals eager to learn and follow the science, fostering your growth in a truly collaborative and global team

Introduction to Role

The translational PKPD team provides global leadership in DMPK science on Antibody Drug Conjugates (ADCs) and Radioconjugates (RCs) at AstraZeneca. We advise drug discovery project teams on DMPK and PKPD strategy, explore the PK/PD/Efficacy relationships in pre-clinical models, use

these models to build quantitative understanding of the dose & schedule requirements for therapeutic intervention across different cancer patient populations.

Embedded within the Clinical Pharmacology and Quantitative Pharmacology (CPQP) department, we work closely with Clinical Pharmacology colleagues - this positioning provides a unique bridge from discovery to the clinic, offering opportunity to also learn about Drug Clinical Development phases. As an intern, you will help advance our translational PKPD approaches for ADCs and RCs —contributing analyses that inform dose selection, schedule optimization, and mechanistic understanding— while gaining hands-on exposure to model-based decision-making in a highly collaborative, impact-driven environment.

AstraZeneca has partnered with the Royal Society of Chemistry’s Broadening Horizons in the Chemical Sciences programme,, to support chemists from minoritised racial and ethnic backgrounds pursue careers in the chemical sciences. This internship is being offered exclusively to the Broadening Horizons Cohort to support this programme and our commitments to it.”

Accountabilities

• complete required onboarding and technical training, including PK/PD fundamentals and software tools; proactively seek guidance to close knowledge gaps

deliver assigned project(s) to agreed milestones, working independently day-to-day while seeking input on critical decisions

communicate and share results and findings regularly to team members and to other forums as appropriate

reflect on learning objectives, track skills acquired, and deliver a final presentation summarizing project objectives, methods, results

Essential Criteria

• Currently undertaking a PhD in Chemical or Biological Engineering, Mathematics, or similar field
• Strong communication skills and ability to work independently
  
  

Desirable

• Familiarity/Experience with ADME and PKPD aspects of large molecules
• Familiarity/Experience with PKPD (and related) mathematical modelling
• Hands-on experience with Matlab, Simcyp, R, or other PKPD-relevant software
  
  

AstraZeneca is where you can immerse yourself in groundbreaking work with real patient impact.

Trusted to work on important projects, you’ll have the independence to take on new challenges while receiving all the guidance you need to succeed. Our collaborative environment is designed to help you grow professionally and personally, surrounded by passionate individuals eager to make a difference.

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca, starting with the recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics.

We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any reasonable adjustments/accommodations, please complete the section in the application form.

Ready to make an impact? Apply now and join us on this

exciting journey!

#Earlytalent

Date Posted

26-Jan-2026

Closing Date

09-Feb-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.