Associate Principal Scientist - In Vivo Pharmacology (Kidney Disease and Metabolic Disease)
CompanySygnature Discovery
Location
Nottingham, England, United Kingdom
Employment TypeFull-time
Posted At6/5/2026
UK Visa Sponsorship Analytics
Analytics are greyed out due to low classification confidence (39.0%).
Occupation Code Skill LevelHigher Skilled
Sponsorship Salary Threshold
£41,700
(£21.38 per hour)
Standard minimum applies
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Description
About Sygnature Discovery
At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.
We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.
Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 200+ patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.
About the role:
We are seeking a highly motivated Associate Principal Scientist to join our In Vivo Pharmacology team in Nottingham. This is an exciting opportunity to play a key role in client-sponsored drug discovery programmes within a dynamic, fast-paced preclinical CRO environment.
Working at the forefront of translational science, you will bring your expertise in kidney disease and potentially metabolic disorders to design, lead and deliver high-quality in vivo studies, contributing directly to the advancement of innovative therapeutics.
Please note that this is a full-time onsite position.
Role Responsibilities:
At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.
We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.
Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 200+ patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.
About the role:
We are seeking a highly motivated Associate Principal Scientist to join our In Vivo Pharmacology team in Nottingham. This is an exciting opportunity to play a key role in client-sponsored drug discovery programmes within a dynamic, fast-paced preclinical CRO environment.
Working at the forefront of translational science, you will bring your expertise in kidney disease and potentially metabolic disorders to design, lead and deliver high-quality in vivo studies, contributing directly to the advancement of innovative therapeutics.
Please note that this is a full-time onsite position.
Role Responsibilities:
- Lead the design, execution and interpretation of in vivo pharmacology studies within kidney and metabolic disease programmes.
- Act as Project Lead, coordinating multidisciplinary teams to deliver high-quality, timely outcomes for client projects.
- Provide scientific leadership and technical expertise, guiding experimental strategy and solving complex research challenges.
- Drive innovation, implementing novel experimental approaches and technologies to enhance project success and improve scientific capabilities and workflows within the department.
- PhD in a relevant discipline with industry or postdoctoral drug discovery experience or BSc/MSc with substantial industry experience in drug discovery.
- Strong expertise in kidney disease. Expertise and experience in metabolic disorders is advantageous.
- Proven experience applying in vivo pharmacology models in drug discovery; expertise in relevant ex vivo assays is highly desirable.
- Experience with end-to-end drug discovery workflows and industrial drug discovery is advantageous.
- Strong understanding of UK regulations governing in vivo research.
- Demonstrated experience in study design, oversight and data interpretation.
- Strong organisational and project management capabilities, with the ability to manage multiple projects simultaneously.
- Effective communicator with proven ability to collaborate across teams and with clients.
- 🌴 25 days annual leave (plus bank holidays)
- 🏥 Private Medical Insurance
- 🛡️ Life Insurance
- 🎯 Employee Assistance Programme
- ⚖️ Enhanced Family Friendly Policies
- 💰 Sygnature Group Pension Scheme
- 💚 1 paid volunteer day per year