Clinical Bioinformatician -- Mat Cover

The postholder will contribute to the development, validation and implementation of Artificial Intelligence and Machine Learning methodologies to enhance genomic data analysis and interpretation in a clinical setting. Working within the Translational Research and Bioinformatics team, the Research Bioinformatician will support translational research, optimise data pipelines for high-throughput sequencing, and integrate AI/ML approaches into clinical workflows. The role involves close collaboration with clinicians, scientists, data engineers and external partners to ensure research outputs are robust, reproducible and clinically relevant.

In addition, the postholder will design and develop web portals for data visualisation, support scientists with NGS data analysis and interpretation, and manage data storage, backup and user support. They will also contribute to staff training, documentation and SOPs, ensuring compliance with legal and ethical standards for handling and transmitting genetic and sensitive patient data

The main objective of the post holder is to provide expert bioinformatics knowledge and support for the provision and development of next generation sequencing (NGS) data analysis in Clinical Genomics both for diagnostic and R&D applications. They will contribute to the development of analysis pipelines and state of the art web portal necessary to provide an efficient and high quality clinical genomics service for cancer patients. Responsibilities of the post holder will include designing, implementing and maintaining NGS data analysis pipelines for a range of applications including custom enrichment panels, whole exome sequencing, gene expression profiling as well as genome-wide methylation analysis.

In addition, the post holder will also involved in designing web portal for data visulisation and supporting Clinical Scientists and research scientist to analyse and interpret NGS report. Moreover, the post holder will be responsible for storage and backup of NGS data, user support, delivering staff training, writing standard operating procedures and other documents as well as ensuring that the department complies with legal and professional requirements in regards to storage and transmission of patient’s genetic and sensitive data.

The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make

a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals – one in Chelsea, London, and one in Sutton, Surrey – as well as a Medical Daycare Unit in Kingston Hospital.

At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do.

At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements.

For further details / informal visits contact: Name: Lina Yuan Job title: Head of Clinical Bioinformatics Email address: lina.yuan@rmh.nhs.uk