Computational Chemist (Senior Scientist I/ Senior Scientist II)
CompanyOMass Therapeutics
Location
Oxford, England, United Kingdom
Employment TypeFull-time
Posted At3/19/2026
UK Visa Sponsorship Analytics
Analytics are greyed out due to low classification confidence (42.0%).
Occupation TypeChemical scientists
Occupation Code Skill LevelHigher Skilled
Sponsorship Salary Threshold
£39,900
(£20.46 per hour)
Immigration salary list rate applies
✓ On immigration salary list - lower visa fees apply
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Description
Job type: Full-time
Location: Oxford, with hybrid working options available
Salary: Competitive salary
Right to work: You must have the right to work in the UK
Application deadline: 10th April
OMass Therapeutics is a biotechnology company based in Oxford discovering medicines against highly- validated target ecosystems, such as membrane proteins or intracellular complexes. The company's unique OdyssION™ technology platform comprises novel biochemistry techniques, next-generation native mass spectrometry and custom formatted compound libraries for ultra-high throughput screening. OMass is advancing a pipeline of small molecule therapeutics in rare diseases and immunological conditions, that target solute carriers, complex-bound proteins, and GPCRs, with biophysical platform technologies at the core of drug discovery.
We are seeking a Computational Chemist. You will be part of a dynamic and innovative environment and will become an integral part of our vision to address patients' unmet needs while building Britain's Biggest Biotech. You will use your cheminformatics/computational chemistry expertise and scientific curiosity to solve drug discovery challenges, as part of multi-disciplinary project teams. You will be able to work in state-of-the-art laboratory and modern facilities for optimum collaboration alongside a focused and caring team.
You will already possess expert Computational Chemistry knowledge with experience in both Ligand and Structure-Based Design with industry experience in small molecule drug discovery.
Discover more about OMass and our Employee Value Proposition here.
Requirements
Essential Experience, Skills and Qualities
Location: Oxford, with hybrid working options available
Salary: Competitive salary
Right to work: You must have the right to work in the UK
Application deadline: 10th April
OMass Therapeutics is a biotechnology company based in Oxford discovering medicines against highly- validated target ecosystems, such as membrane proteins or intracellular complexes. The company's unique OdyssION™ technology platform comprises novel biochemistry techniques, next-generation native mass spectrometry and custom formatted compound libraries for ultra-high throughput screening. OMass is advancing a pipeline of small molecule therapeutics in rare diseases and immunological conditions, that target solute carriers, complex-bound proteins, and GPCRs, with biophysical platform technologies at the core of drug discovery.
We are seeking a Computational Chemist. You will be part of a dynamic and innovative environment and will become an integral part of our vision to address patients' unmet needs while building Britain's Biggest Biotech. You will use your cheminformatics/computational chemistry expertise and scientific curiosity to solve drug discovery challenges, as part of multi-disciplinary project teams. You will be able to work in state-of-the-art laboratory and modern facilities for optimum collaboration alongside a focused and caring team.
You will already possess expert Computational Chemistry knowledge with experience in both Ligand and Structure-Based Design with industry experience in small molecule drug discovery.
Discover more about OMass and our Employee Value Proposition here.
Requirements
Essential Experience, Skills and Qualities
- Ph.D. in cheminformatics/computational chemistry or equivalent industrial experience
- Experience of working across multiple target-types including membrane bound GPCRs & solute carriers and soluble proteins
- Familiarity with Dotmatics and Schrodinger software suites in addition to a sound knowledge of chemical toolkits (e.g. RDKit) is preferred
- Demonstrated ability to critically assess and communicate QSAR/ machine learning model limitations, uncertainty, and suitability for program use
- Experience centred on lead optimisation and later stage project cycles, with the capability to independently lead the computational elements of the design-make-test-analyse (DMTA) cycle
- Experience of working in a matrix team
- Promote and maintain the highest levels of scientific excellence in computational chemistry, to help deliver OMass' pipeline objectives
OMass offers an excellent benefits package including:
- Private Health Insurance
- Health and wellbeing cashback scheme
- Life Assurance and Income Protection
- Participation in Employee Equity Scheme
- 25 days annual leave, plus bank holidays
- Pension Scheme offering 6% employer contribution
- Learning and Development Opportunities
- Company social events
OMass Therapeutics values diversity and is committed to equality of opportunity, we also have full responsibility to ensure that all employees are eligible to work and live in the UK.