Marie Curie ON-Tract PhD position (Fixed Term)
UK Visa Sponsorship Analytics
Analytics are greyed out due to low classification confidence (21.0%).
Occupation Type
Non-commissioned officers and other ranks
Occupation Code Skill LevelIneligible
Sponsorship EligibilityIneligible for Sponsorship
Above analytics are generated algorithmically based on job titles and may not always be the same as the company's job classification. You can also check detailed occupation eligibility, and salary criteria on our UK Visa Eligible Occupations & Salary Thresholds page.
Disclaimer: Hunt UK Visa Sponsors aggregates job listings from publicly available sources, such as search engines, to assist with your job hunting. We do not claim affiliation with University of Cambridge. For the most up-to-date job details, please visit the official website by clicking "Apply Now."
Description
PhD Position - Marie Curie network ON-Tract: Protein engineering of enzymes: in vitro directed evolution and machine learning-based elaboration of biocatalysis for synthesis.
A doctoral position is available for 3-years to work with Professor Florian Hollfelder at the Biochemistry Department of Cambridge University (https://hollfelder.bioc.cam.ac.uk/). The project is part of the Horizon Europe Eu Marie Curie Network ON-TRACT (www.on-tract.eu/) and involves collaborations with various EU and UK groups engaged in using oligonucleotides for therapeutic purposes, including anti-cancer therapy.
This project will develop ultrahigh throughput for in vitro evolution of enzymes used in synthetic chemistry relevant for oligonucleotide constructs (chiral synthesis: IREDs, ligases). Starting from diverse libraries made by error-prone PCR, site-saturation mutagenesis and transposon-based InDel mutagenesis in vitro selections will be carried out, followed by long-read nanopore sequencing and deep mutational scanning of the screening output. This approach selects new, efficient enzymes, but also generates unique sequencefunction datasets that will be interpreted by regression and tree-based machine learning algorithms to obtain even better mutants and develop mechanistic hypotheses.
Various collaborations with ON-TRACT network partners across Europe allow a particularly wide skills training, including organic synthesis, cell biological and medical work.
Applicants should thus have a first (or upper second) class degree in chemistry, biochemistry or a related, relevant subject. Familiarity with molecular and chemical biology techniques and specific skills in assay development, enzyme kinetics, DNA library generation, structural biology, organic synthesis, high-throughput screening, mechanistic enzymology, bioinformatics and microfluidic engineering are advantages.
Applications should contain a description of research interests (e.g. as part of the cover letter), a detailed CV (with exam marks and all relevant practical experience) and a list of publications. Please also include the names and email addresses of at least two referees, who are familiar with your research work.
Fixed-term: The funds for this post are available until 31st January 2029, in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
For informal enquiries,
A doctoral position is available for 3-years to work with Professor Florian Hollfelder at the Biochemistry Department of Cambridge University (https://hollfelder.bioc.cam.ac.uk/). The project is part of the Horizon Europe Eu Marie Curie Network ON-TRACT (www.on-tract.eu/) and involves collaborations with various EU and UK groups engaged in using oligonucleotides for therapeutic purposes, including anti-cancer therapy.
This project will develop ultrahigh throughput for in vitro evolution of enzymes used in synthetic chemistry relevant for oligonucleotide constructs (chiral synthesis: IREDs, ligases). Starting from diverse libraries made by error-prone PCR, site-saturation mutagenesis and transposon-based InDel mutagenesis in vitro selections will be carried out, followed by long-read nanopore sequencing and deep mutational scanning of the screening output. This approach selects new, efficient enzymes, but also generates unique sequencefunction datasets that will be interpreted by regression and tree-based machine learning algorithms to obtain even better mutants and develop mechanistic hypotheses.
Various collaborations with ON-TRACT network partners across Europe allow a particularly wide skills training, including organic synthesis, cell biological and medical work.
Applicants should thus have a first (or upper second) class degree in chemistry, biochemistry or a related, relevant subject. Familiarity with molecular and chemical biology techniques and specific skills in assay development, enzyme kinetics, DNA library generation, structural biology, organic synthesis, high-throughput screening, mechanistic enzymology, bioinformatics and microfluidic engineering are advantages.
Applications should contain a description of research interests (e.g. as part of the cover letter), a detailed CV (with exam marks and all relevant practical experience) and a list of publications. Please also include the names and email addresses of at least two referees, who are familiar with your research work.
Fixed-term: The funds for this post are available until 31st January 2029, in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
For informal enquiries,
please contact Professor Florian Hollfelder via fh111@cam.ac.uk
For queries regarding the application process, please contact the Biochemistry HR Team via: personnel@bioc.cam.ac.uk
Please quote reference PH48293 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
For queries regarding the application process, please contact the Biochemistry HR Team via: personnel@bioc.cam.ac.uk
Please quote reference PH48293 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.