Scientist, Translational Medicine

Location of role Oxford, UK

Department Translational Medicine

Key Responsibilities MAIN PURPOSE OF JOB

To design, develop and validate fit-for-purpose custom pharmacokinetic and immunogenicity assays used in ImmTAC programs and conduct experiments to characterize in-vivo exposure, pharmacodynamic response and clinical impact.

Key Responsibilities

• Design and build custom LBA and/or cell-based pharmacokinetic and immunogenicity assays suitable for use in stage appropriate clinical studies.
• Assist with PK modelling and simulations using software such as phoenix and biomath assess. Working knowledge of R (and packages such as dplyr) would be advantageous.
• Lead technical transfer of validation-ready assays to suitable third-party laboratory vendors, and oversee method validation studies according to regulatory guidance and industry best practices
• Monitor CRO assay performance and sample analysis; review and summarize PK and ADA results
• Participate in clinical study teams as bioanalytical representative to coordinate sample collection, analysis and reporting according to established timelines

Design and execute exploratory bioanalytical projects; interpret data and make recommendations for next steps/future directions

Support preclinical studies as required to aid construct nomination and MOA investigations

Design and characterize custom reagents, controls and biological matrices for use in bioanalytical assays; effectively manage inventory of applicable study samples, reagents and controls.

Keep abreast of technical advances in relevant fields through self-study and attending training sessions and conferences.

Communicate results internally in lab meetings and seminars and externally in relevant conferences.

Operate in accordance with the company’s health and safety policies.

PERSON SPECIFICATION

Experience & knowledge

• Working knowledge and understanding of bioanalytical assays for protein macromolecules with strong scientific and technical skills in method development and validation
• A minimum of 3 years of hands-on experience in the development and validation of quantitative immunoassays and immunogenicity assays for biologics (e.g. antibodies, proteins or peptides)

Experience in aseptic cell culture and cell-based assay development

Familiar with current regulatory guidance and industry best practices for development and validation of bioanalytical methods for large molecule biologics

Experience in GLP and/or clinical regulatory compliance

Strong analytical skills, and a demonstrated ability to work both independently and in a team setting

Excellent verbal and written communication skills

Education & Qualifications

PhD with 0-2 years of relevant professional experience in immunology, biochemistry or related discipline. Or MSc degree or BSc with equivalent, relevant experience.

WORK ENVIRONMENT

This job operates both in a cat 2 laboratory environment and in a professional office environment. The scientist needs to adhere to the Company’s code of practice, health and safety procedures, and rules governing the use of human tissue samples as per the Company’s policies.

POSITION TYPE AND EXPECTED HOURS OF WORK / TRAVEL

This is a full-time position. Days and hours of work are Monday through Friday, 9:00 a.m. to 5:30 p.m. (4:15 Friday)

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.<

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Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.