Senior Scientist – Oncology Research, Functional Pharmacology | FTC 7 months
UK Visa Sponsorship Analytics
Analytics are greyed out due to low classification confidence (39.0%).
Occupation Type
Natural and social science professionals not elsewhere classified.
Occupation Code Skill LevelHigher Skilled
Sponsorship Salary Threshold
£41,700
(£21.38 per hour)
Standard minimum applies
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Description
Location of role Oxford, UK
Department Oncology Research
Key Responsibilities The incumbent is expected to have strong working knowledge deriving deep mechanistic immuno-biology insight into our therapeutic platforms and disease indications of strategic interest and play a pivotal role in generating pharmacology data on new drug formats/platforms, dissecting drug MOA and immunophenotyping response and resistance mechanisms. Should also demonstrate emerging knowledge of drug development process.
To build advanced in vitro assays to model the tumour microenvironment (TME) models and test hypotheses. To establish combination screening workflows designed to explore the pharmacology of agents, including standard-of-care anti-cancer drugs, on target/disease biology and immune cell activation and redirected killing.
Key Responsibilities
Department Oncology Research
Key Responsibilities The incumbent is expected to have strong working knowledge deriving deep mechanistic immuno-biology insight into our therapeutic platforms and disease indications of strategic interest and play a pivotal role in generating pharmacology data on new drug formats/platforms, dissecting drug MOA and immunophenotyping response and resistance mechanisms. Should also demonstrate emerging knowledge of drug development process.
To build advanced in vitro assays to model the tumour microenvironment (TME) models and test hypotheses. To establish combination screening workflows designed to explore the pharmacology of agents, including standard-of-care anti-cancer drugs, on target/disease biology and immune cell activation and redirected killing.
Key Responsibilities
- Pharmacology: Lead projects and collaborate with colleagues to build pharmacology data on new drug formats (e.g. TCRm, multi-specifics) and effectors (including immune checkpoint- / cytokine-enhanced drugs and alternative cell effectors (e.g. myeloid))
- Collaborate with colleagues to build a deep knowledge around drug targets and cancer indications of strategic interest to Immunocore.
- Proactively contribute to internal project / programme team meetings. Generate and communicate knowledge and data packages to solve complex problems and help inform go / no-go decisions
Essential
- Strong working knowledge and understanding of immunology and cancer cell biology
- Significant prior pharmacology experience, testing the effects of therapeutic molecules and combinations on tumour biology, immune cell activation and cancer cell killing
- Broad experience with a broad range of immunoassay techniques, including isolation of primary human immune cells and proficiency in lymphocyte (T-cell, NK) and myeloid (TAMs, MDSC) functional assays and endpoints (measuring proliferation and cytokines, flow cytometry, ELISA etc.)
- Experienced in generating in vitro models of cancer that model complex TMEs through immune and/or stromal cell co-culture
- High throughput screening
- 3D in vitro modelling experience (e.g., organoid, spheroid, tissue slice, organ-on-chip)
- Experience with omics technologies (i.e., bulk and single cell genomics/transcriptomics)
- Bioinformatic expertise (e.g., R, Python)
- Microscopy (e.g., confocal, single molecule, super-resolution, TIRF, live and fixed cell)
- In vivo pharmacology experience
- PhD or equivalent in Immunology, Immuno-oncology, Pharmacology, Oncology, Molecular Cell Biology, Biochemistry, or similar discipline
- 3+ years’ experience of post-doctoral research in an academic or industrial setting
- Or, MSc degree or BSc degree with role-specific equivalent research or industrial experience.
About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and s
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and s
upporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.