Associate Principal Scientist – In Vivo Pharmacology (Kidney Disease or Metabolic Disease)

About Sygnature Discovery

At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.

We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.

Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 200+ patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.

About the role:

We are seeking two highly motivated Associate Principal Scientists to join our In Vivo Pharmacology team and provide scientific leadership across complex client-sponsored drug discovery programmes, helping to progress novel therapeutics towards the clinic.

We're looking for two experienced scientists to join the team: one with expertise in kidney disease and one with expertise in metabolic disease. Working at the forefront of translational science, you'll design, lead and deliver high-quality in vivo studies, contributing directly to the advancement of innovative therapeutics.

Unlike traditional pharmaceutical roles focused on a single pipeline, you'll have the opportunity to work directly with biotechnology and pharmaceutical clients, influencing a diverse portfolio of drug discovery programmes and applying your expertise across multiple therapeutic projects.

Whether your background is in kidney disease or metabolic disease (experience in inflammation would also be advantageous), you'll play a key role in shaping experimental strategy, driving scientific innovation and delivering high-quality pharmacology studies that accelerate the development of life-changing medicines.

Please note this is a full-time, onsite position based in Nottingham.

Role Responsibilities:

• Lead the design, execution and interpretation of in vivo pharmacology studies within kidney, inflammation and/or metabolic disease programmes.

• Act as Project Lead, coordinating multidisciplinary teams to deliver high-quality, timely outcomes for client projects.

• Provide scientific leadership and technical expertise, guiding experimental strategy and solving complex research challenges.

• Drive innovation, implementing novel experimental approaches and technologies to enhance project success and improve scientific capabilities and workflows within the department.

• Collaborate closely with internal teams and external clients, contributing to study design, data interpretation and scientific discussions.

• Support and mentor team members; line management responsibilities may form part of this role.

Skills & Qualifications:

• PhD in a relevant discipline with industry or postdoctoral drug discovery experience or BSc/MSc with substantial industry experience in drug discovery.

• Strong expertise in kidney disease, inflammation and/or metabolic disorders.

• Proven experience applying in vivo pharmacology models in drug discovery; expertise in relevant ex vivo assays is highly desirable.

• Experience with end-to-end drug discovery workflows and industrial drug discovery is advantageous.

• Strong understanding of UK regulations governing in vivo research.

• Demonstrated experience in study design, oversight and data interpretation.

• Strong organisational and project management capabilities, with the ability to manage multiple projects simultaneously.

• Effective communicator with proven ability to collaborate across teams and with clients.

Benefits

• 🌴 25 days annual leave (plus bank holidays)

• 🏥 Private Medical Insurance

• 🛡️ Life Insurance

• 🎯 Employee Assistance Programme

• ⚖️ Enhanced Family Friendly Policies

• 💰 Sygnature Group Pension Scheme

• 💚 1 paid volunteer day per year

Please note: This advert may close early if we receive a high volume of applications. We encourage you to submit your application as soon as possible to avoid missing out on this opportunity.