Research Associate in Modelling Friedreich's ataxia using iPSC-derived neurons
Added 12 Oct · still live
Possible
Sponsorship likelihood
The pay only meets a lower rate
£40,300
Going rate
Skilled Worker going rate
This role may qualify only on a lower rate
Anyone can use the standard rate, and the pay is below it. If you are a new entrant or a PhD holder, you can use a lower rate, and the pay clears the new entrant rate. On the jobs board, Standard hides roles like this and the new entrant rate shows them as Possible at most.
We pick the code from the advert's text, so it is our best guess, not the employer's. Each code it could be has its own likelihood:
- Possible 2113 (Biochemists and biomedical scientists) · 26% match
Your salary route
New graduate or PhD holder? Pick one of the lower rates.
What each route needs for this job
| Occupation code | New entrant 70% of going rate | STEM PhD 80% of going rate | Relevant PhD 90% of going rate | Standard rate 100% of going rate |
|---|---|---|---|---|
2112 Biological scientists Most likely code | £33,400 Clears | £33,400 Clears | £37,500 Clears | £40,300 Misses |
We use the lowest threshold across the plausible codes. Likelihood is Possible at most when the pay clears only a lower rate, or only under a less likely code. A mark is for the top of the advertised pay. How the Home Office picks the code
About the role
The University of Sheffield is a remarkable place to work. Our people are at the heart of everything we do. Their diverse backgrounds, abilities and beliefs make Sheffield a world-class university.
We offer a fantastic range of benefits including a highly competitive annual leave entitlement (with the ability to purchase more), a generous pensions scheme, flexible working opportunities, a commitment to your development and wellbeing, a wide range of retail discounts, and much more. Find out more about our benefits (opens in a new window) and join us to become part of something special.
Overview
We are looking for an enthusiastic and ambitious Research Associate to join the laboratories of Dr Matt Livesey, Prof Dame Pam Shaw and Profs Mead, Hautbergue and Mortiboys at the Sheffield Institute for Translational Neuroscience (SITraN), supporting research into the cellular mechanisms underlying Friedreich’s ataxia (FA). SITraN is an internationally recognised centre of excellence for research into neurodegenerative diseases and therapeutic development.
Funded to support an FA research programme, the successful candidate will play a key role in developing and delivering research investigating disease mechanisms and the effects of novel therapeutic compounds using human induced pluripotent stem cell (iPSC)-derived neuronal models. The post holder will be responsible for planning and undertaking experimental studies, generating, analysing and interpreting data, and contributing to the development of new approaches to understand FA pathophysiology and therapeutic responses.
The role will primarily involve the generation, characterisation and experimental use of human iPSC-derived neuronal models. Experimental approaches will include iPSC culture and differentiation, immunocytochemistry, fluorescence microscopy, whole-cell patch-clamp electrophysiology, molecular biology and RNA sequencing. The post holder will develop and optimise protocols, troubleshoot technical challenges and integrate cellular, electrophysiological and molecular datasets.
The successful candidate will work collaboratively within a multidisciplinary team while demonstrating independence in planning and delivering their research. They will contribute to publications, presentations, research reports and future funding applications, and may provide guidance to students and less experienced researchers.
We are seeking a scientist with a PhD and experience in neuroscience, neurobiology, molecular biology, cell biology or a related discipline. Experience of human iPSC models, neuronal differentiation and/or relevant experimental techniques would be advantageous.
All candidates are encouraged to contact Matt Livesey for an informal chat prior to applying.
Main Duties And Responsibilities
We offer a fantastic range of benefits including a highly competitive annual leave entitlement (with the ability to purchase more), a generous pensions scheme, flexible working opportunities, a commitment to your development and wellbeing, a wide range of retail discounts, and much more. Find out more about our benefits (opens in a new window) and join us to become part of something special.
Overview
We are looking for an enthusiastic and ambitious Research Associate to join the laboratories of Dr Matt Livesey, Prof Dame Pam Shaw and Profs Mead, Hautbergue and Mortiboys at the Sheffield Institute for Translational Neuroscience (SITraN), supporting research into the cellular mechanisms underlying Friedreich’s ataxia (FA). SITraN is an internationally recognised centre of excellence for research into neurodegenerative diseases and therapeutic development.
Funded to support an FA research programme, the successful candidate will play a key role in developing and delivering research investigating disease mechanisms and the effects of novel therapeutic compounds using human induced pluripotent stem cell (iPSC)-derived neuronal models. The post holder will be responsible for planning and undertaking experimental studies, generating, analysing and interpreting data, and contributing to the development of new approaches to understand FA pathophysiology and therapeutic responses.
The role will primarily involve the generation, characterisation and experimental use of human iPSC-derived neuronal models. Experimental approaches will include iPSC culture and differentiation, immunocytochemistry, fluorescence microscopy, whole-cell patch-clamp electrophysiology, molecular biology and RNA sequencing. The post holder will develop and optimise protocols, troubleshoot technical challenges and integrate cellular, electrophysiological and molecular datasets.
The successful candidate will work collaboratively within a multidisciplinary team while demonstrating independence in planning and delivering their research. They will contribute to publications, presentations, research reports and future funding applications, and may provide guidance to students and less experienced researchers.
We are seeking a scientist with a PhD and experience in neuroscience, neurobiology, molecular biology, cell biology or a related discipline. Experience of human iPSC models, neuronal differentiation and/or relevant experimental techniques would be advantageous.
All candidates are encouraged to contact Matt Livesey for an informal chat prior to applying.
Main Duties And Responsibilities
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- Take responsibility for planning, conducting and interpreting a programme of experimental research investigating the cellular mechanisms underlying Friedreich’s ataxia and the effects of potential therapeutic compounds.
- Design and undertake experiments using human iPSC-derived neuronal models, including the maintenance, expansion and differentiation of iPSC cultures into relevant neuronal cell types.
- Develop, optimise and validate experimental protocols and methodologies to address specific research questions, identifying and resolving technical challenges where appropriate.
- Apply a range of experimental approaches, which may include immunocytochemistry, fluorescence microscopy, molecular biology, RNA extraction and analysis, whole-cell patch-clamp electrophysiology and RNA sequencing.
- Undertake quantitative analysis and interpretation of experimental datasets, integrating cellular, electrophysiological and molecular findings to address research hypotheses.
- Maintain accurate and comprehensive experimental records, research data and sample inventories, ensuring that all work is conducted to appropriate standards of scientific rigour and reproducibility.
- Contribute to the development of new experimental approaches and research directions within the FA programme, working collaboratively with Dr Matt Livesey, supervisors, technical staff and the wider laboratory.
- Take responsibility for the day-to-day delivery of defined research objectives and contribute to project planning, prioritisation and the achievement of agreed milestones.
- Prepare research findings for presentation at laboratory meetings, conferences and other scientific meetings, and contribute to the preparation of manuscripts, reports and research outputs.
- Contribute to the preparation of research proposals and funding applications where appropriate, supporting the development of future research activities within the programme.
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Our diverse community of staff and students recognises the unique abilities, backgrounds, and beliefs of all. We foster a culture where everyone feels they belong and is respected. Even if your past experience doesn't match perfectly with this role's criteria, your contribution is valuable, and we encourage you to apply. Please ensure that you reference the application criteria in the application statement when you apply.
Criteria
Essential Or Desirable
Stage(s) assessed at
A minimum of PhD in Neuroscience or related subject
Essential
Application/interview
Demonstrable experience of working with and leading projects using induced pluripotent stem cell (iPSC) models
Essential
Application/interview
Expertise in neurodegeneration
Desirable
Application/interview
Demonstrable experience in conducting research as part of collaborative team
Essential
Application/interview
Experience in the maintenance of iPSC in culture and the derivation of iPSC neurons
Desirable
Application/interview
Experience in immunocytochemistry (ICC), fluorescence microscopy, RNA extraction and molecular biology techniques
Desirable
Application/interview
Experience in patch-clamp electrophysiology
Desirable
Application/interview
Maintain accurate records
Essential
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Application/interview
Participating in weekly team meetings
Essential
Application/interview
Presentation of data internally and at international conferences
Essential
Application/interview
Further Information
Grade
Grade 7
Salary
£38,784 to £47,389
Work arrangement
Full-time
Duration
As soon as possible. End date 27-07-2028
Line manager
Dr Matt Livesey
Direct reports
Dr Matt Livesey
Right to work in the UK
If you do not currently hold the right to work in the UK, you can find more information here to help determine your visa eligibility. Additional guidance is also available on the UK Visa & Immigration website.
Our website
https://sheffield.ac.uk/sitran
For informal enquiries about this job contact Matt Livesey, project lead: on [email protected]
Next steps in the recruitment process
It is anticipated that the selection process will take place early October. This will consist of INTERVIEW and PRESENTATION. We plan to let candidates know if they have progressed to the selection stage on the week commencing one week after closing date. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact Dr Matt Livesey.
Our vision and strategic plan
We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision (opens in new window).
What We Offer
Participating in weekly team meetings
Essential
Application/interview
Presentation of data internally and at international conferences
Essential
Application/interview
Further Information
Grade
Grade 7
Salary
£38,784 to £47,389
Work arrangement
Full-time
Duration
As soon as possible. End date 27-07-2028
Line manager
Dr Matt Livesey
Direct reports
Dr Matt Livesey
Right to work in the UK
If you do not currently hold the right to work in the UK, you can find more information here to help determine your visa eligibility. Additional guidance is also available on the UK Visa & Immigration website.
Our website
https://sheffield.ac.uk/sitran
For informal enquiries about this job contact Matt Livesey, project lead: on [email protected]
Next steps in the recruitment process
It is anticipated that the selection process will take place early October. This will consist of INTERVIEW and PRESENTATION. We plan to let candidates know if they have progressed to the selection stage on the week commencing one week after closing date. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact Dr Matt Livesey.
Our vision and strategic plan
We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision (opens in new window).
What We Offer
- A minimum of 41 days annual leave including bank holiday and closure days (pro rata) with the ability to purchase more.
- paid time off for parenting and caring emergencies
- access to menopause support in the workplace
- paid time off and support for fertility treatment
- and more
We are a Disability Confident Leader (opens in a new window). If you have a disability and meet the essential criteria for this job you will be invited to take part in the next stage of the selection process.
Possession of a criminal record is not an automatic bar to employment at the University of Sheffield. We recognise the value of steady employment in the rehabilitation process and examine each case in its own right. More information can be found on our Information for candidates page:- sheffield.ac.uk/jobs/candidates (opens in a new window).
We are a research university with a global reputation for excellence. Our ideas and expertise change the world for the better, making a real difference to society. We know that when people come together with different views, approaches and insights it can lead to richer, more creative and innovative teaching and research and the highest levels of student experience. Our University Vision (www.sheffield.ac.uk/vision) outlines our commitment to building a diverse community of staff and students that recognises and values the abilities, backgrounds, beliefs and ways of living for everyone.
This description is the source posting as it read when we added it. We are not affiliated with The University of Sheffield, so check their own site for the current details.
Where this offer sits in the market
Biological scientists (SOC 2112) · UK · ONS ASHE 2025 · basic pay · ~14k in sampleSOC 2112
- Middle half £32,448–~56,472
- Median £44,460
- Minimum £41,700
- Going rate £40,300
- New entrant £33,400–36,300
Similar sponsored roles
See all UK visa jobsNo close matches live right now.
Browse more sponsored jobs at The University of SheffieldAbout sponsorship for this role
Does this job guarantee visa sponsorship?
Not necessarily. The University of Sheffield holds a sponsor licence, but sponsorship for a specific hire is always the employer's decision. Be upfront in your application that you'll require it.
What salary is needed for this role to be eligible?
The offer must clear both the general threshold and the SOC 2112 going rate of £40,300. New-entrant and shortage discounts can lower it.